阴道乳杆菌胶囊对产后6周妇女
特异性阴道炎防治作用的临床探讨
黄新颜，罗伟东，洪展彤，刘丹
南方医科大学附属佛山市妇幼保健院妇女保健科，广东佛山
摘要:目的探讨微生物制剂(阴道乳杆菌胶囊)对产后6周妇女特异性阴道炎(细菌性阴道病、滴虫性阴道炎、外阴阴道念珠菌病)的防治作用。方法采用前瞻性研究方法。自年6月至年8月先后收集例产后6周特异性阴道炎妇女，包括细菌性阴道病例、外阴阴道念珠菌病例和滴虫性阴道炎21例，随机分成三组，第一组(n=)阴道局部用乳杆菌胶囊(定君生)mg/d，连用10d;第二组(n=)阴道局部用抗菌药(细菌性阴道病或滴虫性阴道炎:甲硝唑栓mg/d，外阴阴道念珠菌病:克霉唑栓mg/d，连用10d);第三组(n=)阴道局部用抗菌药+乳杆菌胶囊(细菌性阴道病或滴虫性阴道炎:甲硝唑栓mg/d+定君生mg/d，外阴阴道念珠菌病:克霉唑栓mg/d+定君生mg/d，连用10d)，三组均于停药1周后复查阴道分泌物以了解疗效，以及产后3、6、9、12个月分别复查阴道分泌物，以了解三组产后1年内阴道pH、乳杆菌数量变化情况及阴道炎复发率情况。结果例产后6周特异性阴道炎妇女中，单用定君生治疗组总有效率为76．5%;用甲硝唑栓或克霉唑栓治疗组总有效率为77．5%;两组总疗效比较差异无统计学意义(P＜0.5)。用抗菌药(甲硝唑栓或克霉唑栓)+定君生治疗组总有效率为95.0%，与前两组比较差异有统计学意义(P＜0.5)。应用定君生治疗两组1年内阴道pH明显降低，阴道乳酸杆菌数量明显增多，以+++～++++比例为主，且追踪1年阴道炎的发生率均明显降低，与只用抗生素治疗组相比差异有统计学意义(P＜0.05)。结论阴道乳杆菌胶囊(定君生)是治疗特异性阴道炎的有效药物，与传统抗生素相比疗效差异无统计学意义，且定君生联合抗生素治疗特异性阴道炎，疗效更为显著，这不失为一个新的治疗途径。产后6周妇女特异性阴道炎选用微生态制剂(阴道乳杆菌胶囊)，能防止因使用抗生素引发的耐药性、二重感染、过敏反应以及对机体的毒副作用等弊端，提高特异性阴道炎的治愈率，减少复发和再生率，有利于恢复产后妇女阴道微生态平衡，从而起到防病治病的目的，值得临床推广。
关键词:阴道乳杆菌胶囊;产后6周;特异性阴道炎;防治
中图分类号:Ｒ．31文献标志码:A
文章编号:-X()05--06
Clinicalinvestigationontheeffectsoflacidophilinvaginalcapsuleforpreventionandtreatmentofspecificvaginitisatsixweekspostpartum
HUANGXin-yan，LUOWei-dong，HONGZhan-tong，LIUDan
WomenHealthCareDepartmentofFoshanWomenandChildrensHospitalAffiliatedtoChinaSouthernMedicalUniversity，Foshan，ChinaCorrespondingauthor:HUANGXin-yan，Email:huangxinyan
．ComAbstract:ObjectiveTostudytheeffectsofmicrobialagent(lacidophilinvaginalcapsule)forpreventionandtreatmentofspecificvaginitis(bacterialvaginosis，trichomonasvaginitis，vulvovaginalcandidiasis)amongwomenatsixweekspostpartum．MethodsProspectivestudymethodwasused．womenwithspecificvaginitisatsixweekspostpartumwereenrolledfromJunetoAugustsuccessively，includingcasesofbacterialvagi-nosis，casesofvulvovaginalcandidiasis，and21casesoftrichomonasvaginitis．Thepatientsweredividedran-domlyintothreegroups．Group1(cases)wasgivenintravaginallymgoflacidophilincapsuledailyfor10days，Group2(cases)wasgivenantimicrobialagent(mgofMetronidazoleSuppositorydailyforbacterialvaginosisortrichomonas，mgofClotrimazoleSuppositorydailyforvulvovaginalcandidiasis)for10days，whileGroup3(cases)wasgivenantimicrobialagent(mgofMetronidazoleSuppositoryormgofclotrimazolesuppository)andmgoflacidophilincapsuledailyfor10days．Thevaginalsecretionwasre-examinedoneweekafterdrugwithdrawal，andatthethird，sixth，ninethandtwelvethmonthspostpartumtolearnthevaginalpH，changeoflactobacilluscountingandtherecurrencerateofspecificvaginitis．ResultsTheoverallefficacyrateinthegroup1was76.5%，whilethatinthegroup2was77．5%;therewasnosignificantdifferencebetweenthetwogroups(P0.05)．TheoverallefficacyrateinGroup3was95.0%，significantlydifferentfromthoseintheothertwogroups(P0.05)．VaginalpHvaluesreducedandtheamountofvaginallactobacillusincreasedobviouslya-mongwomenwhousedlacidophilincapsule，andtherecurrencerateofspecificvaginitisreducedobviouslytoo，withsignificantdifferencefromthegrouptreatedwithantibiotics(P0.05)．ConclusionLacidophilincapsuleiseffectivefortreatmentofspecificvaginitis，especiallywhen
